Neurodegenerative disease is an umbrella term for a variety of conditions that mainly influence human brain cells. Neurons are the nervous system’s construction blocks that include the brain and spinal cord. Neurons do generally not reproduce or replace themselves, so they cannot be substituted by the body when they get harmed or die.
Neuro-degeneration is the gradual loss of neuron structure or function, including neuron death. Many neurodegenerative diseases happen as a consequence of neurodegenerative procedures, including ALS, Parkinson’s, Alzheimer’s, and Huntington’s.
CBD & NEURODEGENERATION
It is currently possible to separate “cannabinoids” (CBD) into three distinct groups: endogenous (endocannabinoids), synthetic, and phytocannabinoids. The latter group involves terpene phenolic substances obtained from Cannabis sativa, such as CBD and CBD. Two membrane receptors for CBD, both combined with Gi protein, named CB1 and CB2, have been identified to date.
An accumulation of iron in the brain is a prevalent component observed in each of these illnesses. These accumulations, however, are not the cause of disease, but are a side effect that exacerbates each situation. A new article released in the Brain Research Bulletin demonstrates that CBD can safeguard the brains of rats against the impacts of iron accumulation. This study sheds light on the prospective use of CBD as a means of treating neurodegeneration-related symptoms.
Study
Rat brain MT health has been evaluated in several respects. First, they looked at harm to MT DNA. MTs have their genome separate from ours, unlike the other “organ” of a cell. Accumulated iron interferes with normal metabolism, producing chemicals that can harm MT DNA. If this damage is not correctly repaired, parts of DNA will be removed from the genome, possibly disrupting the genes needed for MT function. The writers discovered that there were more deletions of DNA from healthy rat MTs from rats with iron poisoning than from DNA. This indicates that iron accumulations attack mts DNA in the brain.
CBD therapy did not have any impact on the growth of these deletions, but this is probably to have an effect on their methodology. Interestingly, CBD therapy improved the expression of this gene back to normal levels.
It seems particularly desirable to make an early contribution of neuroprotective and anti-inflammatory strategies to these disorders because isolated treatments cannot be efficient. Particular interest has been drawn in this competition by marijuana derivatives, although these compounds have always raised several practical and ethical issues for their prospective abuse. However, cannabidiol (CBD), which lacks any unwanted psychotropic impact, can be a very successful agent with the most significant potential for therapeutic use among cannabis compounds.
CBD FOR TREATMENT OF NEUROGENERATIVE DISORDERS
Anecdotal evidence supports the notion that CBD can play a beneficial role in various neurodegenerative diseases, such as PD and Huntington’s disease (HD), alone or in conjunction with THC, two chronic disorders caused by degenerative mechanisms involving specific nuclei of the basal ganglia that are accountable for abnormal movement control.
CBD’s significant and well-documented antioxidant, anti-inflammatory, and neuroprotective properties led scientists to assess its impacts on neurotoxicity models and neurodegenerative disorders. In this context, auspicious results in the control of toxicity caused by β-amyloid were achieved.
Also, against hyperkinetic illnesses, CBD was considered a compound with therapeutic potential. More lately, CBD has been shown to prevent the toxicity of 3nitropropionic acid in striatal neurons, a mitochondrial toxin that can cause specific biochemical changes comparable to those in HD.
The Bottom Line
This new data emphasizes CBD as a potential neurodegenerative disease therapy. Although it will not cure or reverse cognitive decline, it may slow down the process and provide a better quality of life for those struggling with these particular conditions.
